Fenbendazole is a broad spectrum benzimidazole anthelmintic used in dogs, cats, cattle, horses, sheep, rabbits and fish tanks as well as freshwater shrimp tanks. It is effective against giardia, roundworms, hookworms, whipworms, pinworms and the tapeworm genus Taenia (but not Dipylidium caninum). It is also believed to have efficacy against some of the trematodes associated with gastrointestinal disease including Heterobilharzia americana and Nanophyetus salmincola.
It can be given by mouth or intravenously. Occasionally, the initial dose of the medication can cause coughing in some pets but is usually followed by rapid improvement and full recovery within 7 to 10 days. The medication must be administered for 3-5 consecutive days to kill parasites. The medication should not be given to pet poultry that is actively growing new feathers (ie molting).
Treatment of EMT6 tumors with fenbendazole did not alter the radiation response, as shown in Table 1, which includes data from a previous experiment examining continuous treatment with a fenbendazole-containing diet. The mice were anesthetized with 100 mg/kg ketamine and 10 mg/kg xylazine and the tumors were irradiated locally in the chest or abdomen using 10 Gy of 250 kV ionizing radiation delivered in a Siemens Stabilipan with 0.6 mm Al filtration, as described (8-10).
Complete blood counts on arrival at the laboratory demonstrated that leukocyte responses in the fenbendazole group were similar to those in the control groups; however, the irradiated fenbendazole group did show lower total white cell and neutrophil counts at study termination than did the untreated irradiated controls. fenben lab fenbendazol
ashdev